On November 5, 1972, Mayfield Road Baptist Mission began meeting at Amos Elementary School with 73 people attending Sunday school. Rev. Bill Hamilton served as mission pastor. During this time, work began on the new building at 1701 E. Mayfield Road. The congregation worshipped for the first time in the new building on June 10, 1973. After the resignation of Rev. Hamilton, Dr. Jimmie Nelson came as interim pastor in August.
Rev. Bennie Slack was called as the first full-time pastor on December 2, 1973; and Bill Grisham began as part-time minister of music and youth.
After a one-year period of being self-supporting, the church concluded its mission status on September 8, 1974. With the adoption of a constitution and bylaws, and an unanimous vote from the Mission Committee and congregation, the growing mission became Mayfield Road Baptist Church.
As the church grew, needs for space also grew. On March 17, 1976, the church launched a "Together We Build" campaign to raise funds for a new educational building. Construction began in June, and completion and occupation occurred on February 20, 1977. Building bonds were issued for construction of a new, 500-seat auditorium, and construction began in October 1979. The congregation worshipped for the first time in the new auditorium on May 3, 1981.
After a very successful ministry at Mayfield Road, Rev. Slack resigned as pastor on January 24, 1982; and Dr. Nelson was again called to serve as interim pastor. In April 1982, Dr. Bob Maddox was called as pastor of the church, and he began on the field June 27, 1982. Nineteen months later, Dr. Maddox resigned as pastor to accept a position with "Americans United for Separation of Church and State" in Washington, D.C.
For the third time, Dr. Nelson was called to serve as interim pastor.
On August 1, 1983, Rev. Frank Ashby took the field as pastor. It was during this time that the Mayfield Road Baptist Church celebrated its tenth anniversary on September 10, 1984.
Dr. Ashby resigned as pastor four years later, November 15, 1987. Rev. Chuck Reynolds was called to serve as interim pastor.
On June 26, 1988, the church called Dr. Gary Baldwin as its fifth pastor to take the field on August 8.
Mayfield Road Baptist Church began two worship services and two Sunday school sessions in October 1992. The spring of 1993 saw the return to one worship service and one Sunday school. Later that year, the last of the bonds issued to build the new sanctuary were paid.
Dr. Baldwin resigned as pastor on February 16, 1994, after over five years of service; and Dr. Harold Freeman was called as interim pastor.
Work began in May on Mayfield Rd. to make it a four-lane divided parkway.
On September 11, 1994, Mayfield Road Baptist Church celebrated its twentieth anniversary. Robert Stewart was called as pastor in May 1995. In 1996, a "Gold is Old" sanctuary remodeling campaign began, and by September 1997, the remodeling was completed.
In August 1998, Mr. Stewart resigned as pastor after four years of service. Dr. Nelson came to serve as interim pastor for a fourth time.
On June 6, 1999, Bobby Bridges became the pastor.
On September 26, 1999, Mayfield Road Baptist Church celebrated twenty-five years as a church body.